The Virgin of the Rocks, National Gallery, London, 1503-1506 (great controversy by scholars over the attribution to Leonardo da Vinci).  Note the homogeneous structure of the rocks extending upward, as well as the hard edges that give them an artificial look.  The massive rocks in the foreground display no geological detail.  The flora is also diverse throughout the picture.  The plants in the foreground resemble cultivated annuals needs considerably more light than world be available in the grotto.

The Virgin of the Rocks, Louvre, Paris, 1483-1486 by Leonardo da Vince. The difference in the textures of the rocks from the top to the bottom of the painting reflect actual geological features.  The flora are indigenous to the depicted environment.